Epibrassinolide-78821-43-9-C28H48O6 -Chemindustry.com - The leading vertical market advertising source for the chemical world

CAS No.: 78821-43-9 Formula: C28H48O6

Weight: 480.677

Synonyms: Brassinolide; 24-Epibrassinolide; (3aS,5S,6R,7aR,7bS,9aS,10R,12aS,12bS)-10-[(2S,3R,4R,5S)-3,4-dihydroxy-5,6-dimethylheptan-2-yl]-5,6-dihydroxy-7a,9a-dimethylhexadecahydro-3H-benzo[c]indeno[5,4-e]oxepin-3-one; (3aS,5S,6R,7aR,7bS,9aS,10R,12aS,12bS)-10-[(2S,3R,4R,5R)-3,4-dihydroxy-5,6-dimethylheptan-2-yl]-5,6-dihydroxy-7a,9a-dimethylhexadecahydro-3H-benzo[c]indeno[5,4-e]oxepin-3-one; (3aS,5S,6R,7aR,7bS,9aS,12aS,12bS)-10-[(1S,2S,3R,4R)-2,3-dihydroxy-1,4,5-trimethylhexyl]-5,6-dihydroxy-7a,9a-dimethylhexadecahydro-3H-benzo[c]indeno[5,4-e]oxepin-3-one;

Description

Epibrassinolide(EBR)isabiologicallyactivecompoundofthebrassinosteroids,steroid-derivedplantgrowthregulatorfamily.Cellsareincubatedwithvariousdoses(0-100μM)ofEpibrassinolidefor24or48handcellviabilityisdeterminedbyMTTassay.Epibrassinolideinducedcellviabilitylossindose-andtime-dependentmannercomparedtountreatedsamplesinLNCaPandDU145prostatecancercells.IncreasingconcentrationsofEpibrassinolideismoreeffectiveonLNCaPcChemicalbookellviabilitylossthanDU145cellssuggestingthatandrogen-dependentcellsaremoresensitivetoEpibrassinolidethanandrogen-independentprostatecancercells.Infurtherexperiments,25μMEpibrassinolideisselectedduetoitsmoderatecytotoxiceffectonbothcelllines.TheeffectofEpibrassinolidetreatmentisexaminedoncellproliferationbycountingthecellnumberwithin96h.AhigherandearlierinhibitionofcellproliferationisobservedinLNCaPthanDU145cells.

Basic Information

CAS No.:

78821-43-9

Synonyms:

Brassinolide; 24-Epibrassinolide; (3aS,5S,6R,7aR,7bS,9aS,10R,12aS,12bS)-10-[(2S,3R,4R,5S)-3,4-dihydroxy-5,6-dimethylheptan-2-yl]-5,6-dihydroxy-7a,9a-dimethylhexadecahydro-3H-benzo[c]indeno[5,4-e]oxepin-3-one; (3aS,5S,6R,7aR,7bS,9aS,10R,12aS,12bS)-10-[(2S,3R,4R,5R)-3,4-dihydroxy-5,6-dimethylheptan-2-yl]-5,6-dihydroxy-7a,9a-dimethylhexadecahydro-3H-benzo[c]indeno[5,4-e]oxepin-3-one; (3aS,5S,6R,7aR,7bS,9aS,12aS,12bS)-10-[(1S,2S,3R,4R)-2,3-dihydroxy-1,4,5-trimethylhexyl]-5,6-dihydroxy-7a,9a-dimethylhexadecahydro-3H-benzo[c]indeno[5,4-e]oxepin-3-one;

Formula:

C28H48O6

Molecular Weight:

480.677

PSA:

LogP:

Properties

Appearance & Character:

White to Off-White

Density:

1.141g/cm³

Melting Point:

256°C

Boiling Point:

633.7°C at 760 mmHg

Flash Point:

202.3°C

Storage Conditions:

-20°C

Safety Info

Customs Code:

29372900

WGK Germany:

3

Hazard Category Code:

22-36/37/38

Security Instructions:

22-36/37/39-45