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4-(4-Methylpiperazinomethyl)benzoic Acid Dihydrochloride

CAS No.: 106261-49-8      Formula: C13H22Cl2N2O3

Weight: 325.23100

Synonyms: 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride; 4-[(4-methylpiperazin-1-yl)methyl]benzoic acid,dihydrochloride; 4-[(4-Methyl-1-piperazinyl)methyl]benzoic acid dihydrochloride;




Description

Imatinib, the first generation of tyrosine kinase inhibitor, is a milestone drug in the history of treating chronic myeloid leukemia (CML). It was launched by Novartis in 2001 and is a model of successful targeted therapy Chemicalbook. It only kills BCR-ABL contained in myeloid cells, prevents cell proliferation and tumor formation, but has no effect on normal cells. It can also inhibit PDGF-mediated tumors, including glioma and prostate cancer.

Basic Information
CAS No.:
106261-49-8
Synonyms:
4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride; 4-[(4-methylpiperazin-1-yl)methyl]benzoic acid,dihydrochloride; 4-[(4-Methyl-1-piperazinyl)methyl]benzoic acid dihydrochloride;
Formula:
C13H22Cl2N2O3
Molecular Weight:
325.23100
PSA:
53.01000
LogP:
2.54770
Properties
Appearance & Character:
Yellow to Dark Yellow
Density:
1.345g/cm3
Melting Point:
305-307ºC
Boiling Point:
495.6ºC at 760mmHg
Flash Point:
253.5ºC
Storage Conditions:
Keep in dark place,Inert atmosphere,2-8°C
Safety Info
Customs Code:
2933599090
Hazard Category Code:
R22; R36/37/38
Security Instructions:
S22-S26-S36/37/39
Dangerous Goods Sign:
Xn