service@chemindustry.com
Sign in    |    Register    |    

Tetracaine hydrochloride

CAS No.: 136-47-0      Formula: C15H25ClN2O2

Weight: 300.82400

Synonyms: Benzoic acid, 4-(butylamino)-, 2-(dimethylamino)ethyl ester, monohydrochloride; 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester,Ameth; Tetracaine (hydrochloride); Tetracaine HCl; curtacain;




Description

Tetracaine (also known as amethocaine) is a local anesthetic of the ester anesthetic group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia. In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely. Tetracaine is the T in TAC, a mixture of 5 to 12 per cent tetracaine, 0.05 per cent adrenaline, and 4 or 10 per cent cocaine hydrochloride used in ear, nose & throat surgery and in the emergency department where numbing of the surface is needed rapidly, especially when children have been injured in the eye, ear, or other sensitive locations. It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system. A systematic review investigated tetracaine for use in emergency departments, especially for IV cannulation in children, in view of its analgesic and cost-saving properties. However, it did not find an improvement in first attempt cannulations.

Basic Information
CAS No.:
136-47-0
Synonyms:
Benzoic acid, 4-(butylamino)-, 2-(dimethylamino)ethyl ester, monohydrochloride; 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester,Ameth; Tetracaine (hydrochloride); Tetracaine HCl; curtacain;
Formula:
C15H25ClN2O2
Molecular Weight:
300.82400
PSA:
41.57000
LogP:
3.49200
Properties
Appearance & Character:
White or grayish white crystalline powder
Density:
Melting Point:
149°C
Boiling Point:
389.4ºC at 760 mmHg
Flash Point:
189.3ºC
Storage Conditions:
Keep tightly closed.
Safety Info
Customs Code:
2942000000
Hazard Category Code:
R25; R36; R43
Security Instructions:
S26-S36/37-S45-S36/37/39-S22-S53
Dangerous Goods Sign:
T