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lamivudine

CAS No.: 134678-17-4      Formula: C8H11N3O3S

Weight: 229.25600

Synonyms: 2',3'-Dideoxy-3'-thiacytidine; Heptovir; Epivir; 4-Amino-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one; 3&L-SddC; 3TC; cent; (-)-1-[(2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine; Lamivudine; Zeffix; Zefix; Hepitec; Heptivir;




Description

Lamivudine, commonly called 3TC, is an antiretroviral medication used to prevent and treat HIV/AIDS. It is also used to treat chronic hepatitis B when other options are not possible. It is effective against both HIV-1 and HIV-2. It is typically used in combination with other antiretrovirals such as zidovudine and abacavir. Lamivudine may be included as part of post-exposure prevention in those who have been potentially exposed to HIV. Lamivudine is taken by mouth as a liquid or tablet. Common side effects include nausea, diarrhea, headaches, feeling tired, and cough. Serious side effects include liver disease, lactic acidosis, and worsening hepatitis B among those already infected. It is safe for people over three months of age and can be used during pregnancy. The medication can be taken with or without food. Lamivudine is a nucleoside reverse transcriptase inhibitor and works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase. Lamivudine was first approved for use in the United States in 1995. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system. It is available as a generic medication. The wholesale cost in the developing world as of 2014 is about 0.06 USD per day. As of 2015 the cost for a typical month of medication in the United States is more than 200 USD.

Basic Information
CAS No.:
134678-17-4
Synonyms:
2',3'-Dideoxy-3'-thiacytidine; Heptovir; Epivir; 4-Amino-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one; 3&L-SddC; 3TC; cent; (-)-1-[(2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine; Lamivudine; Zeffix; Zefix; Hepitec; Heptivir;
Formula:
C8H11N3O3S
Molecular Weight:
229.25600
PSA:
115.67000
LogP:
-0.01290
Properties
Appearance & Character:
White Crystalline Powder
Density:
1.73g/cm3
Melting Point:
177 °C
Boiling Point:
475.4ºC at 760 mmHg
Flash Point:
241.3ºC
Storage Conditions:
Freezer
Safety Info
Customs Code:
2934999090