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N-iodosuccinimide

CAS No.: 516-12-1      Formula: C4H4INO2

Weight: 224.98500

Synonyms: 2,5-Pyrrolidinedione, 1-iodo-; N-Iodosuccinimide; 1-iodopyrrolidine-2,5-dione; N-Iodosuccinimide (NIS);




Description

N-Iodosuccinimide is a iodo substituted succinimide that is used as an iodinating agent in chemical synthesis. production method: 1. In the dark condition, make succinimide react with silver oxide to prepare N-succinimide silver. It reacts with iodine in dry dioxane to generate N-iodosuccinimide. 2. Put 20 grams (0.079 moles) of iodine and 90 ml of dry dioxane in a wide-mouth, screw-cap brown bottle with a capacity of 150-200 ml, most of the iodine is dissolved. 18 grams (0.087 moles) of thoroughly dried silver N-butadiimide were added. The bottle was shaken vigorously for a few minutes, the mixture was shaken occasionally over the next 1 hour, and then heated in a 50°C water bath for 5 minutes. Strain hot through a Buchner funnel into well-wrapped black paper or aluminum foil. milliliter filter bottle. Collect silver iodide and wash with 10 mL of hot dioxane. Combine the filtrate in the filter flask, add 200 ml of carbon tetrachloride, let the solution cool at -8 ℃ to -20 ℃ overnight, and N-iodosuccinic imide becomes colorless crystals. Collect in a Buchner funnel with as little exposure to light as possible, wash with 25 mL of carbon tetrachloride, and dry with suction. Dry overnight at 25°C/1m rn in the dark.

Basic Information
CAS No.:
516-12-1
Synonyms:
2,5-Pyrrolidinedione, 1-iodo-; N-Iodosuccinimide; 1-iodopyrrolidine-2,5-dione; N-Iodosuccinimide (NIS);
Formula:
C4H4INO2
Molecular Weight:
224.98500
PSA:
37.38000
LogP:
0.42330
Properties
Appearance & Character:
白色至灰白色粉末
Density:
2,245 g/cm3
Melting Point:
202-206 °C(lit.)
Boiling Point:
249.6ºC at 760 mmHg
Flash Point:
104.8ºC
Storage Conditions:
2-8ºC
Safety Info
Signal Word:
Warning
Customs Code:
29251995
WGK Germany:
3
Hazard Category Code:
R22; R36/37/38
Security Instructions:
S26-S36-S37/39
Dangerous Goods Sign:
Xn