CAS No.: 94105-90-5 Formula: C15H14O3
Weight: 242.27
Synonyms: 7,4'-HoMoisoflavane; NV; 07α; 3-(4-Hydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-7-ol; 7-Hydroxy-3-(4-hydroxyphenyl)chroman; 4',7-Isoflavandiol; 3,4-Dihydro-3-(4-hydroxyphenyl)-2H-chromen-7-ol;
Equolisfirstisolatedandidentifiedfrompregnant-mares'urineandlaterfoundintheurineofthegoat,cow,henandsheep.Equol,unlikethesoyisoflavonesdaidzeinorgenistein,hasachiralcenterandthereforecanoccuras2distinctdiastereoisomers.S-equolistheexclusiveproductofhumanintestinalbacterialsynthesisfromsoyisoflavonesandbothenantiomersarebioavailable.S-equolhasahiChemicalbookghaffinityforestrogenreceptorbeta(Ki=0.73nM),whereasR-equolisrelativelyinactive.EquolcouldpromotetheproliferationanddifferentiationofratosteoblaststhroughactivatingtheER-PKCα-relatedsignalingpathway.Thealkalinephosphataseactivityalsoincreasessignificantlyinalloftheequoland17β-estradiol(E2)groups.Equolalsosignificantlyelevatestheosteocalcinlevels.