leflunomide-75706-12-6-C12H9F3N2O2 -Chemindustry.com - The leading vertical market advertising source for the chemical world

CAS No.: 75706-12-6 Formula: C12H9F3N2O2

Weight: 270.20700

Synonyms: Leflunomida; Leflunomidum; 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide; Leflunomide; lefunamide; Leflunomid; Arava; HWA 486; N-(4-trifluoromethyl-phenyl)-5-methylisoxazole-4-carboxamide;

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Description

Leflunomide (original brand name Arava) is an immunosuppressive disease-modifying antirheumatic drug (DMARD), used in active moderate-to-severe rheumatoid arthritis and psoriatic arthritis. It is a pyrimidine synthesis inhibitor that works by inhibiting dihydroorotate dehydrogenase. Bottle of Leflunomide (Arava) and tablet

Basic Information

CAS No.:

75706-12-6

Synonyms:

Leflunomida; Leflunomidum; 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide; Leflunomide; lefunamide; Leflunomid; Arava; HWA 486; N-(4-trifluoromethyl-phenyl)-5-methylisoxazole-4-carboxamide;

Formula:

C12H9F3N2O2

Molecular Weight:

270.20700

PSA:

55.13000

LogP:

3.32710

Properties

Appearance & Character:

Gray-White crystalline solid

Density:

1.392 g/cm3

Melting Point:

163-168°C

Boiling Point:

289.3ºC at 760 mmHg

Flash Point:

128.8ºC

Storage Conditions:

2-8ºC

Safety Info

Symbol:

GHS06

Signal Word:

Dangerous

Hazard Statement:

H301; H315; H319; H335

Warning Statement:

P261; P301 + P310; P305 + P351 + P338

Customs Code:

2934999090

WGK Germany:

3

Hazard Category Code:

R22; R36/37/38

Security Instructions:

S26; S36

Dangerous Goods Sign:

Xn