4-(4-Methylpiperazinomethyl)benzoic Acid Dihydrochloride
CAS No.: 106261-49-8 Formula: C13H22Cl2N2O3
Weight: 325.23100
Synonyms: 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride; 4-[(4-methylpiperazin-1-yl)methyl]benzoic acid,dihydrochloride; 4-[(4-Methyl-1-piperazinyl)methyl]benzoic acid dihydrochloride;
Imatinib, the first generation of tyrosine kinase inhibitor, is a milestone drug in the history of treating chronic myeloid leukemia (CML). It was launched by Novartis in 2001 and is a model of successful targeted therapy Chemicalbook. It only kills BCR-ABL contained in myeloid cells, prevents cell proliferation and tumor formation, but has no effect on normal cells. It can also inhibit PDGF-mediated tumors, including glioma and prostate cancer.