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7,8-DIHYDROXYFLAVONE

CAS No.: 38183-03-8      Formula: C15H10O4

Weight: 254.23700

Synonyms: 7,8-dihydroxy-2-phenylchromen-4-one; 7,8-Dihydroxyflavone Hydrate; 7,8-Dihydroxy-2-phenyl-4H-chromen-4-one; 7,8-Dihydroxyflavone


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Description

7,8-Dihydroxyflavone (7,8-DHF) is a naturally-occurring flavone found in Godmania aesculifolia, Tridax procumbens, and primula tree leaves. It has been found to act as a potent and selective small-molecule agonist of the TrkB receptor (Kd ≈ 320 nM), the main signaling receptor of brain-derived neurotrophic factor (BDNF). 7,8-DHF is both orally-bioavailable and able to penetrate the blood-brain-barrier. 7,8-DHF has demonstrated remarkable therapeutic efficacy in animal models of a variety of central nervous system disorders, including depression, Alzheimer's disease, cognitive deficits in schizophrenia, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, traumatic brain injury, cerebral ischemia, fragile X syndrome, and Rett syndrome. 7,8-DHF also shows efficacy in animal models of age-associated cognitive impairment and enhances memory consolidation and emotional learning in healthy rodents. In addition, 7,8-DHF possesses powerful antioxidant activity independent of its actions on the TrkB receptor, and protects against glutamate-induced excitotoxicity, 6-hydroxydopamine-induced dopaminergic neurotoxicity, and oxidative stress-induced genotoxicity. It was also found to block methamphetamine-induced dopaminergic neurotoxicity, an effect which, in contrast to the preceding, was found to be TrkB-dependent.

Basic Information
CAS No.:
38183-03-8
Synonyms:
7,8-dihydroxy-2-phenylchromen-4-one; 7,8-Dihydroxyflavone Hydrate; 7,8-Dihydroxy-2-phenyl-4H-chromen-4-one; 7,8-Dihydroxyflavone
Formula:
C15H10O4
Molecular Weight:
254.23700
PSA:
70.67000
LogP:
2.87120
Properties
Appearance & Character:
Density:
1.443g/cm3
Melting Point:
243-246°C
Boiling Point:
494.4ºC at 760 mmHg
Flash Point:
193.5ºC
Storage Conditions:
Safety Info
Signal Word:
Warning
Customs Code:
2914400090
Security Instructions:
S24/25