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3-((3-Cholamidopropyl)dimethylammonium)-1-propanesulfonate

CAS No.: 75621-03-3      Formula: C32H58N2O7S

Weight: 614.87700

Synonyms: CHAPS,HighPurity; CHAPS Solution; CHAPS ELECTROPHORESIS REAGENT; CHAPS extrapure; TREND;


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Description

CHAPS is a zwitterionic surfactant used in the laboratory to solubilize biological macromolecules such as proteins. It may be synthesized from cholic acid and is zwitterionic due to its quaternary ammonium and sulfonate groups; it is structurally similar to certain bile acids, such as taurodeoxycholic acid and taurochenodeoxycholic acid. It is used as a non-denaturing solvent in the process of protein purification and is especially useful in purifying membrane proteins, which are often sparingly soluble or insoluble in aqueous solution due to their native hydrophobicity. CHAPS is an abbreviation for 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate. A related detergent, called CHAPSO, has the same basic chemical structure with an additional hydroxyl functional group; its full chemical name is 3-[(3-cholamidopropyl)dimethylammonio]-2-hydroxy-1-propanesulfonate. Both detergents have low light absorbance in the ultraviolet region of the electromagnetic spectrum, which is useful for laboratory workers monitoring ongoing chemical reactions or protein-protein binding with UV/Vis spectroscopy.

Basic Information
CAS No.:
75621-03-3
Synonyms:
CHAPS,HighPurity; CHAPS Solution; CHAPS ELECTROPHORESIS REAGENT; CHAPS extrapure; TREND;
Formula:
C32H58N2O7S
Molecular Weight:
614.87700
PSA:
155.37000
LogP:
4.35380
Properties
Appearance & Character:
Density:
1.01 g/mL at 20ºC
Melting Point:
156-158ºC
Boiling Point:
Flash Point:
Storage Conditions:
Safety Info
Signal Word:
Danger
Customs Code:
2934999090
Hazard Category Code:
R36/37/38
Dangerous Goods Sign:
Xi