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niclosamide

CAS No.: 50-65-7      Formula: C13H8Cl2N2O4

Weight: 327.12000

Synonyms: hl2447; 2',5-Dichloro-4'-nitrosalicylanilide; 2’,5-dichloro-4’-nitrosalicylanilide; iomezan; Niclosamide; clonitralid; nasemo; iomesan; sulqui; b2353; bay2353; lintex; mato; fenasal; 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide;


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Description

Niclosamide (trade name Niclocide) is a teniacide in the anthelmintic family especially effective against cestodes that infect humans and many other animals. It is a salicylanilide compound (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydrobenzamide) also used as a piscicide. While antihelmintics are a drug family used to treat worm infections, niclosamide is used specifically to treat tapeworms and is not effective against other worms such as pinworms or roundworms. It is a chewable tablet taken orally, dosage depending on type of worm and patient's age and/or weight. It is not usually considered the drug of choice for treating cestode infection in humans or animals because of its side effects, though it remains highly effective and is generally inexpensive. Along with oxyclozanide, another tapeworm drug, it has been recently found to display "strong in vivo and in vitro activity against methicillin-resistant Staphylococcus aureus (MRSA)". It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system.

Basic Information
CAS No.:
50-65-7
Synonyms:
hl2447; 2',5-Dichloro-4'-nitrosalicylanilide; 2’,5-dichloro-4’-nitrosalicylanilide; iomezan; Niclosamide; clonitralid; nasemo; iomesan; sulqui; b2353; bay2353; lintex; mato; fenasal; 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide;
Formula:
C13H8Cl2N2O4
Molecular Weight:
327.12000
PSA:
95.15000
LogP:
4.45570
Properties
Appearance & Character:
white to yellowish odourless crystalline powder
Density:
1.616g/cm3
Melting Point:
225-230ºC
Boiling Point:
424.5ºC at 760 mmHg
Flash Point:
210.5ºC
Storage Conditions:
Safety Info
Signal Word:
Warning
Customs Code:
2924299090
WGK Germany:
2