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Triclabendazole

CAS No.: 68786-66-3      Formula: C14H9Cl3N2OS

Weight: 359.65800

Synonyms: 6-Chloro-5-(2,3-dichlorophenoxy)-2-methylthio-benzimidazole;


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Description

Triclabendazole (commercial names: veterinary, liquid: Fasinex; human, tablets: Egaten, both manufactured by Novartis) is a member of the benzimidazole family of anthelmintics. The benzimidazole drugs share a common molecular structure, triclabendazole being the exception in having a chlorinated benzene ring but no carbamate group. Benzimidazoles such as triclabendazole are generally accepted to bind to beta-tubulin and prevent the polymerization of the microtubules of which they are part. Triclabendazole was initially only developed as an oral route drug, and displays high efficacy against both immature and adult liver flukes. Since late 1990s, triclabendazole became available as a generic drug, as patents expired in many countries. Many products were developed then. Among them, Trivantel 15, a 15% triclabendazole suspension, was launched by Agrovet Market Animal Health in the early 2000s. In 2009, the first triclabendazole injectable solution (combined with ivermectin) was developed and launched, also by Agrovet Market Animal Health. The product, Fasiject Plus, a triclabendazole 36% and ivermectin 0.6% solution, is designed to treat infections by Fasciola hepatica (both immature and adult liver flukes), roundworms and ectoparasites, as well. It is on the World Health Organization's List of Essential Medicines, the most important medication needed in a basic health system.

Basic Information
CAS No.:
68786-66-3
Synonyms:
6-Chloro-5-(2,3-dichlorophenoxy)-2-methylthio-benzimidazole;
Formula:
C14H9Cl3N2OS
Molecular Weight:
359.65800
PSA:
63.21000
LogP:
6.03730
Properties
Appearance & Character:
white to brown crystalline powder
Density:
1.59 g/cm3
Melting Point:
175-176°C
Boiling Point:
495.9ºCat 760 mmHg
Flash Point:
253.7ºC
Storage Conditions:
Safety Info
Customs Code:
2933990090
WGK Germany:
3
Hazard Category Code:
R36/37/38
Security Instructions:
S26; S36
Dangerous Goods Sign:
Xn