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Colchicine

CAS No.: 64-86-8      Formula: C22H25NO6

Weight: 399.44

Synonyms: Acetamide, N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)-; Benzo(a)heptalen-9(5H)-one, 7-acetamido-6,7-dihydro-1,2,3,10-tetramethoxy-; N-(1,2,3,10-Tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide; N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)acetamide; N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide; N1-(1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide; N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide;


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Description

Colchicine has a good effect on acute gout, can quickly relieve pain and prevent arthritis attacks. Its mechanism of action is related to inhibiting the proliferation and activity of leukocytes and affecting the release of lysosomes. The pharmacological effect of this product is to reduce the activity and phagocytosis of leukocytes in the inflammatory tissue and reduce the inflammation of Chemicalbook caused by uric acid crystals, thereby exerting anti-inflammatory, swelling and analgesic effects, so it has selective anti-inflammatory effects on acute gouty arthritis. effect. In addition, this product is also a mitotic toxin, which has a strong inhibitory effect on cell division, making cells stop in the division phase, resulting in tumor cell death, so it can be used for cancer treatment.

Basic Information
CAS No.:
64-86-8
Synonyms:
Acetamide, N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)-; Benzo(a)heptalen-9(5H)-one, 7-acetamido-6,7-dihydro-1,2,3,10-tetramethoxy-; N-(1,2,3,10-Tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide; N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)acetamide; N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide; N1-(1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide; N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide;
Formula:
C22H25NO6
Molecular Weight:
399.44
PSA:
LogP:
Properties
Appearance & Character:
white to yellow with a green cast
Density:
1.2770 (rough estimate)
Melting Point:
150-160 °C (dec.)(lit.)
Boiling Point:
522.37°C (rough estimate)
Flash Point:
Storage Conditions:
2-8°C
Safety Info
Customs Code:
29399990
WGK Germany:
3
Hazard Category Code:
26/28-41-46
Security Instructions:
13-45-36/37/39-28-26-53
Dangerous Goods Sign:
T+,T,Xi